› 3d3m

X-ray diffraction
1.9Å resolution

The Crystal Structure of the C-terminal region of Death Associated Protein 5(DAP5)

Released:
DOI: 10.2210/pdb3d3m/pdb
PDB entry 3d3m coloured by chain, front view.
PDB entry 3d3m coloured by chain, side view.
PDB entry 3d3m coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of the C-terminal DAP5/p97 domain sheds light on the molecular basis for its processing by caspase cleavage.
Liberman N, Dym O, Unger T, Albeck S, Peleg Y, Jacobovitch Y, Branzburg A, Eisenstein M, Marash L, Kimchi A
J Mol Biol 383 539-48 (2008)
PMID: 18722383

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160246 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Eukaryotic translation initiation factor 4 gamma 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 168 amino acids
Theoretical weight: 19.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P78344 (Residues: 730-897; Coverage: 19%)
Gene names: DAP5, EIF4G2, OK/SW-cl.75
Sequence domains: eIF4-gamma/eIF5/eIF2-epsilon
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P21
Unit cell:
a: 61.059Å b: 45.734Å c: 63.357Å
α: 90° β: 103.81° γ: 90°
R-values:
R R work R free
0.214 0.211 0.259
Expression system: Escherichia coli

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Citations

2 review citations

Eukaryotic translation initiation factor eIF4G2 opens novel paths for protein synthesis in development, apoptosis and cell differentiation.
Liu et al. (2023)
1 more

4 mentions without citation

The metaphorical swiss army knife: The multitude and diverse roles of HEAT domains in eukaryotic translation initiation.
Friedrich et al. (2022)
3 more