› 3cxi

X-ray diffraction
1.83Å resolution

Structure of BthTX-I complexed with alpha-tocopherol

Released:
DOI: 10.2210/pdb3cxi/pdb
PDB entry 3cxi coloured by chain, front view.
PDB entry 3cxi coloured by chain, side view.
PDB entry 3cxi coloured by chain, top view.
Source organism: Bothrops jararacussu
Primary publication:
Comparative structural studies on Lys49-phospholipases A(2) from Bothrops genus reveal their myotoxic site.
dos Santos JI, Soares AM, Fontes MR
J Struct Biol 167 106-16 (2009)
PMID: 19401234

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187442 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Basic phospholipase A2 homolog bothropstoxin-I Chains: A, B
Molecule details ›
Chains: A, B
Length: 121 amino acids
Theoretical weight: 13.75 KDa
Source organism: Bothrops jararacussu
UniProt:
  • Canonical: Q90249 (Residues: 17-137; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

3 bound ligands:
Ligand SO4 4 x SO4
Ligand VIT 2 x VIT
Ligand PE4 1 x PE4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE D03B-MX1
Spacegroup: P21
Unit cell:
a: 38.37Å b: 70.13Å c: 43.83Å
α: 90° β: 102.23° γ: 90°
R-values:
R R work R free
0.195 0.195 0.243

Quick links

Citations

3 review citations

Snake venom Lys49 myotoxins: From phospholipases A(2) to non-enzymatic membrane disruptors.
Lomonte et al. (2012)
2 more

8 mentions without citation

Expression, functional, and structural analysis of proteins critical for otoconia development.
Xu et al. (2010)
7 more