› 3cwg

X-ray diffraction
3.05Å resolution

Unphosphorylated mouse STAT3 core fragment

Released:
DOI: 10.2210/pdb3cwg/pdb
PDB entry 3cwg coloured by chain, front view.
PDB entry 3cwg coloured by chain, side view.
PDB entry 3cwg coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structure of unphosphorylated STAT3 core fragment.
Ren Z, Mao X, Mertens C, Krishnaraj R, Qin J, Mandal PK, Romanowski MJ, McMurray JS, Chen X
Biochem Biophys Res Commun 374 1-5 (2008)
PMID: 18433722

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154574 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Signal transducer and activator of transcription 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 562 amino acids
Theoretical weight: 64.42 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P42227 (Residues: 127-688; Coverage: 73%)
Gene names: Aprf, Stat3
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P3121
Unit cell:
a: 254.779Å b: 254.779Å c: 123.781Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.25 0.25 0.268
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

13 review citations

The molecular details of cytokine signaling via the JAK/STAT pathway.
Morris et al. (2018)
12 more

34 mentions without citation

Structural Biology of STAT3 and Its Implications for Anticancer Therapies Development.
Sgrignani et al. (2018)
33 more