› 3c05

X-ray diffraction
1.7Å resolution

Crystal structure of Acostatin from Agkistrodon Contortrix Contortrix

Released:
DOI: 10.2210/pdb3c05/pdb
PDB entry 3c05 coloured by chain, front view.
PDB entry 3c05 coloured by chain, side view.
PDB entry 3c05 coloured by chain, top view.
Source organism: Agkistrodon contortrix contortrix
Primary publication:
Structure of acostatin, a dimeric disintegrin from Southern copperhead (Agkistrodon contortrix contortrix), at 1.7 A resolution.
Moiseeva N, Bau R, Swenson SD, Markland FS, Choe JY, Liu ZJ, Allaire M
Acta Crystallogr D Biol Crystallogr 64 466-70 (2008)
PMID: 18391413

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182334 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Disintegrin acostatin-alpha, processed form Chains: A, C
Molecule details ›
Chains: A, C
Length: 62 amino acids
Theoretical weight: 6.75 KDa
Source organism: Agkistrodon contortrix contortrix
UniProt:
  • Canonical: Q805F7 (Residues: 48-109; Coverage: 68%)
Sequence domains: Disintegrin
Structure domains: Disintegrin domain
Disintegrin acostatin-beta Chains: B, D
Molecule details ›
Chains: B, D
Length: 64 amino acids
Theoretical weight: 6.8 KDa
Source organism: Agkistrodon contortrix contortrix
UniProt:
  • Canonical: Q805F6 (Residues: 419-482; Coverage: 14%)
Sequence domains: Disintegrin
Structure domains: Disintegrin domain

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
1 modified residue:
Ligand PCA 2 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 37.449Å b: 59.808Å c: 121.307Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.186 0.215

Quick links

Citations

1 review citation

Protein complexes in snake venom.
Doley et al. (2009)
9 other articles

8 mentions without citation

Snake Venom Metalloproteinases (SVMPs): A structure-function update.
Olaoba et al. (2020)
7 more