Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134546 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Focal adhesion kinase 1
Molecule details ›
Chains: A, B, C
Length: 162 amino acids
Theoretical weight: 17.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
Sequence domains: Focal adhesion targeting region
Structure domains:
Length: 162 amino acids
Theoretical weight: 17.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
- Canonical:
Q05397 (Residues: 891-1052; Coverage: 15%)
Sequence domains: Focal adhesion targeting region
Structure domains:
T-cell surface glycoprotein CD4
Molecule details ›
Chains: D, E, F
Length: 23 amino acids
Theoretical weight: 2.78 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: T cell CD4 receptor C terminal region
Length: 23 amino acids
Theoretical weight: 2.78 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P01730 (Residues: 428-450; Coverage: 5%)
Sequence domains: T cell CD4 receptor C terminal region
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
ESRF BEAMLINE BM30A
Spacegroup:
C2221
Expression systems:
- Escherichia coli BL21
- Not provided
