› 3apm

X-ray diffraction
2.5Å resolution

Crystal structure of the human SNP PAD4 protein

Released:
DOI: 10.2210/pdb3apm/pdb
PDB entry 3apm coloured by chain, front view.
PDB entry 3apm coloured by chain, side view.
PDB entry 3apm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and biochemical analyses of the human PAD4 variant encoded by a functional haplotype gene.
Horikoshi N, Tachiwana H, Saito K, Osakabe A, Sato M, Yamada M, Akashi S, Nishimura Y, Kagawa W, Kurumizaka H
Acta Crystallogr D Biol Crystallogr 67 112-8 (2011)
PMID: 21245532

Function and Biology Details

Reaction catalysed: 
Protein L-arginine + H(2)O = protein L-citrulline + NH(3)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193952 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein-arginine deiminase type-4 Chain: A
Molecule details ›
Chain: A
Length: 666 amino acids
Theoretical weight: 74.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UM07 (Residues: 1-663; Coverage: 100%)
Gene names: PAD4, PADI4, PADI5, PDI5
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: C2
Unit cell:
a: 145.556Å b: 61.239Å c: 113.474Å
α: 90° β: 123.85° γ: 90°
R-values:
R R work R free
0.286 0.26 0.287
Expression system: Escherichia coli

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Citations

1 review citation

New advances of DNA methylation and histone modifications in rheumatoid arthritis, with special emphasis on MeCP2.
Miao et al. (2013)
10 other articles

1 mention without citation

Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives.
Andreoli et al. (2013)