2zxa Summary


alpha-L-fucosidase complexed with inhibitor, FNJ-acetyl

The structure was published by Wu, H.J., Ho, C.W., Ko, T.P., Popat, S.D., Lin, C.H., and Wang, A.H., in 2010 in a paper entitled "Structural basis of alpha-fucosidase inhibition by iminocyclitols with K(i) values in the micro- to picomolar range." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.57 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Alpha-L-fucosidase, putative.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Alpha-L-fucosidase, putative Q9WYE2 (1-449) (Q9WYE2_THEMA)search Thermotoga maritima MSB8search 100% 455 97%
B Alpha-L-fucosidase, putative Q9WYE2 (1-449) (Q9WYE2_THEMA)search Thermotoga maritima MSB8search 100% 455 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9WYE2 (1 - 449) Alpha-L-fucosidase, putative Thermotoga maritima

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (Q9WYE2) Glycosidasessearch, Golgi alpha-mannosidase IIsearch PF01120: Alpha-L-fucosidasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (Q9WYE2) alpha-L-fucosidase activitysearch fucose metabolic processsearch carbohydrate metabolic processsearch

Chain InterPro annotation
A, B Glycoside hydrolase, family 29search Glycosyl hydrolase, family 13, all-betasearch Glycoside hydrolase, catalytic domainsearch Alpha-L-fucosidase, metazoa-typesearch Glycoside hydrolase superfamilysearch