2zv9 Summary

pdbe.org/2zv9
spacer

Lyn Tyrosine Kinase Domain-PP2 complex

The structure was published by Williams, N.K., Lucet, I.S., Klinken, S.P., Ingley, E., and Rossjohn, J., in 2009 in a paper entitled "Crystal Structures of the Lyn Protein Tyrosine Kinase Domain in Its Apo- and Inhibitor-bound State" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.76 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Tyrosine-protein kinase Lyn. This molecule has the UniProt identifier P25911 (LYN_MOUSE)search. The sample contained 279 residues which is < 90% of the natural sequence. Out of 279 residues 253 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tyrosine-protein kinase Lyn P25911 (239-512) (LYN_MOUSE)search Mus musculussearch < 90% 279 91%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P25911 (239 - 512) Tyrosine-protein kinase Lyn Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO)
A (P25911) protein phosphorylationsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein tyrosine kinase activitysearch ATP bindingsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch