2zv2 Summary


Crystal structure of human calcium/calmodulin-dependent protein kinase kinase 2, beta, CaMKK2 kinase domain in complex with STO-609

The structure was published by Kukimoto-Niino, M., Yoshikawa, S., Takagi, T., et al., Kadowaki, T., Minokoshi, Y., and Yokoyama, S., in 2011 in a paper entitled "Crystal structure of the Ca2+/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Calcium/calmodulin-dependent protein kinase kinase 2. This molecule has the UniProt identifier Q96RR4 (KKCC2_HUMAN)search. The sample contained 298 residues which is < 90% of the natural sequence. Out of 298 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Calcium/calmodulin-dependent protein kinase kinase 2 Q96RR4 (158-448) (KKCC2_HUMAN)search Homo sapienssearch < 90% 298 85%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q96RR4 (158 - 448) Calcium/calmodulin-dependent protein kinase kinase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (Q96RR4) ATP bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Calcium/calmodulin-dependent/calcium-dependent protein kinasesearch