2znc Summary



The structure was published by Stams, T., Chen, Y., Boriack-Sjodin, P.A., et al., Laipis, P., Silverman, D.N., and Christianson, D.W., in 1998 in a paper entitled "Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE IV. This molecule has the UniProt identifier Q64444 (CAH4_MOUSE)search. The sample contained 258 residues which is 90% of the natural sequence. Out of 258 residues 248 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE IV Q64444 (22-279) (CAH4_MOUSE)search Mus musculussearch 90% 258 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q64444 (22 - 279) CARBONIC ANHYDRASE IV Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q64444) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (Q64444) anchored component of external side of plasma membranesearch plasma membranesearch anchored component of plasma membranesearch transport vesicle membranesearch anchored component of membranesearch extracellular vesicular exosomesearch Golgi apparatussearch rough endoplasmic reticulumsearch sarcoplasmic reticulumsearch apical plasma membranesearch endoplasmic reticulum-Golgi intermediate compartmentsearch trans-Golgi networksearch membranesearch sarcolemmasearch perinuclear region of cytoplasmsearch cell surfacesearch brush border membranesearch secretory granule membranesearch response to steroid hormonesearch regulation of pHsearch organ developmentsearch bicarbonate transportsearch one-carbon metabolic processsearch carbon dioxide transportsearch response to drugsearch lyase activitysearch carbonate dehydratase activitysearch zinc ion bindingsearch protein bindingsearch metal ion bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase, CA4search Carbonic anhydrase, alpha-classsearch