2zn9 Summary


Crystal structure of Ca2+-bound form of des3-20ALG-2

The structure was published by Suzuki, H., Kawasaki, M., Inuzuka, T., et al., Shibata, H., Wakatsuki, S., and Maki, M., in 2008 in a paper entitled "Structural Basis for Ca(2+)-Dependent Formation of ALG-2/Alix Peptide Complex: Ca(2+)/EF3-Driven Arginine Switch Mechanism" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Programmed cell death protein 6.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Programmed cell death protein 6 O75340 (20-191) (PDCD6_HUMAN)search Homo sapienssearch 90% 172 98%
B Programmed cell death protein 6 O75340 (20-191) (PDCD6_HUMAN)search Homo sapienssearch 90% 172 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O75340 (20 - 191) Programmed cell death protein 6 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (O75340) EF-handsearch PF13499: EF-hand domain pairsearch, PF13833: EF-hand domain pairsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (O75340) protein bindingsearch calcium-dependent protein bindingsearch calcium ion bindingsearch metal ion bindingsearch binding, bridgingsearch protein dimerization activitysearch protein homodimerization activitysearch calcium-dependent cysteine-type endopeptidase activitysearch extracellular vesicular exosomesearch cytoplasmic vesiclesearch nucleussearch endosomesearch endoplasmic reticulumsearch membranesearch endoplasmic reticulum membranesearch cytoplasmsearch nuclear membranesearch intracellular protein transportsearch apoptotic signaling pathwaysearch cellular response to heatsearch negative regulation of vascular endothelial growth factor receptor signaling pathwaysearch negative regulation of TOR signalingsearch apoptotic processsearch vascular endothelial growth factor receptor-2 signaling pathwaysearch positive regulation of angiogenesissearch activation of cysteine-type endopeptidase activity involved in apoptotic processsearch angiogenesissearch negative regulation of protein kinase B signalingsearch positive regulation of endothelial cell proliferationsearch response to calcium ionsearch proteolysissearch positive regulation of endothelial cell migrationsearch

Chain InterPro annotation
A, B EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch