Complex Structure of Insulin-like Growth Factor Receptor and Isoquinolinedione Inhibitor
The structure was published by Mayer, S.C., Banker, A.L., Boschelli, F., et al., Tkach, D., Tsou, H.R., and Xu, W., in 2008 in a paper entitled "Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2008.
The experimental data on which the structure is based was also deposited.
This PDB entry contains multiple copies of the structure of Insulin-like growth factor 1 receptor.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: