2zlb Summary


Crystal structure of APO form of rat catechol-O-methyltransferase

The structure was published by Tsuji, E., Okazaki, K., Isaji, M., and Takeda, K., in 2009 in a paper entitled "Crystal structures of the Apo and Holo form of rat catechol-O-methyltransferase" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Catechol O-methyltransferase. This molecule has the UniProt identifier P22734 (COMT_RAT)search. The sample contained 223 residues which is < 90% of the natural sequence. Out of 223 residues 212 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Catechol O-methyltransferase P22734 (44-264) (COMT_RAT)search Rattus norvegicussearch < 90% 223 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P22734 (44 - 264) Catechol O-methyltransferase Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A COMT-likesearch Vaccinia Virus protein VP39search O-methyltransferasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P22734) O-methyltransferase activitysearch catechol O-methyltransferase activitysearch magnesium ion bindingsearch neurotransmitter catabolic processsearch catecholamine metabolic processsearch

Chain InterPro annotation
A O-methyltransferase, family 3search Catechol O-methyltransferase, eukaryoticsearch Catechol O-methyltransferasesearch S-adenosyl-L-methionine-dependent methyltransferase-likesearch