2zjc Summary

pdbe.org/2zjc
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TNFR1 selectve TNF mutant; R1-6

The structure was published by Mukai, Y., Shibata, H., Nakamura, T., et al., Kamada, H., Yamagata, Y., and Tsutsumi, Y., in 2009 in a paper entitled "Structure-Function Relationship of Tumor Necrosis Factor (TNF) and Its Receptor Interaction Based on 3D Structural Analysis of a Fully Active TNFR1-Selective TNF Mutant" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Tumor necrosis factor.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tumor necrosis factor P01375 (77-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 157 96%
B Tumor necrosis factor P01375 (77-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 157 96%
C Tumor necrosis factor P01375 (77-233) (TNFA_HUMAN)search Homo sapienssearch < 90% 157 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01375 (77 - 233) Tumor necrosis factor Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C Jelly Rollssearch TNF(Tumour Necrosis Factor) familysearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C (P01375) immune responsesearch tumor necrosis factor receptor bindingsearch membranesearch

Chain InterPro annotation
A, B, C Tumour necrosis factor alphasearch Tumour necrosis factor domainsearch Tumour necrosis factorsearch Tumour necrosis factor-like domainsearch Tumour necrosis factor, conserved sitesearch