2zdt Summary

pdbe.org/2zdt
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Crystal Structure of human JNK3 complexed with an isoquinolone inhibitor

The structure was published by Asano, Y., Kitamura, S., Ohra, T., et al., Yamaguchi, M., Kimura, H., and Fukumoto, S., in 2008 in a paper entitled "Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2)" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 10. This molecule has the UniProt identifier P53779 (MK10_HUMAN)search. The sample contained 364 residues which is < 90% of the natural sequence. Out of 364 residues 342 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 10 P53779 (39-402) (MK10_HUMAN)search Homo sapienssearch 91% 364 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P53779 (39 - 402) Mitogen-activated protein kinase 10 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P53779) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A (P53779) protein phosphorylationsearch protein serine/threonine kinase activitysearch ATP bindingsearch protein kinase activitysearch MAP kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Mitogen-activated protein (MAP) kinase, JNKsearch Protein kinase-like domainsearch