Crystal Structure of human JNK3 complexed with an isoquinolone inhibitor
The structure was published by Asano, Y., Kitamura, S., Ohra, T., et al., Yamaguchi, M., Kimura, H., and Fukumoto, S., in 2008 in a paper entitled "Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2)" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2007.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Mitogen-activated protein kinase 10. This molecule has the UniProt identifier P53779 (MK10_HUMAN). The sample contained 364 residues which is < 90% of the natural sequence. Out of 364 residues 342 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: