2zb1 Summary


Crystal structure of P38 in complex with biphenyl amide inhibitor

The structure was published by Angell, R.M., Bamborough, P., Cleasby, A., et al., Mooney, C.J., Somers, D.O., and Walker, A.L., in 2008 in a paper entitled "Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 345 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q16539) protein phosphorylationsearch positive regulation of myoblast fusionsearch positive regulation of reactive oxygen species metabolic processsearch signal transductionsearch Ras protein signal transductionsearch stress-induced premature senescencesearch negative regulation of canonical Wnt signaling pathwaysearch striated muscle cell differentiationsearch blood coagulationsearch positive regulation of muscle cell differentiationsearch phosphorylationsearch regulation of transcription, DNA-templatedsearch toll-like receptor 5 signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch cellular response to vascular endothelial growth factor stimulussearch positive regulation of blood vessel endothelial cell migrationsearch response to muramyl dipeptidesearch vascular endothelial growth factor receptor signaling pathwaysearch cellular response to lipopolysaccharidesearch innate immune responsesearch neurotrophin TRK receptor signaling pathwaysearch response to lipopolysaccharidesearch skeletal muscle tissue developmentsearch gene expressionsearch cellular component movementsearch peptidyl-serine phosphorylationsearch positive regulation of protein import into nucleussearch cell surface receptor signaling pathwaysearch positive regulation of erythrocyte differentiationsearch intracellular signal transductionsearch toll-like receptor signaling pathwaysearch MyD88-dependent toll-like receptor signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch chondrocyte differentiationsearch response to stresssearch positive regulation of myoblast differentiationsearch RNA metabolic processsearch toll-like receptor 3 signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch stress-activated MAPK cascadesearch MAPK cascadesearch osteoclast differentiationsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch activation of MAPK activitysearch platelet activationsearch transcription, DNA-templatedsearch fatty acid oxidationsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch cellular response to ionizing radiationsearch glucose metabolic processsearch MyD88-independent toll-like receptor signaling pathwaysearch cell morphogenesissearch DNA damage checkpointsearch regulation of transcription from RNA polymerase II promotersearch p38MAPK cascadesearch lipopolysaccharide-mediated signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch regulation of sequence-specific DNA binding transcription factor activitysearch angiogenesissearch positive regulation of myotube differentiationsearch mRNA metabolic processsearch apoptotic processsearch signal transduction in response to DNA damagesearch chemotaxissearch 3'-UTR-mediated mRNA stabilizationsearch cellular response to DNA damage stimulussearch muscle cell differentiationsearch toll-like receptor 4 signaling pathwaysearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch cartilage condensationsearch protein kinase activitysearch ATP bindingsearch MAP kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch kinase activitysearch MAP kinase kinase activitysearch NFAT protein bindingsearch transferase activitysearch protein serine/threonine kinase activitysearch nucleotide bindingsearch nucleussearch nucleoplasmsearch cytoplasmsearch mitochondrionsearch cytosolsearch cellsearch extracellular vesicular exosomesearch spindle polesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch