2zaz Summary


Crystal structure of P38 in complex with 4-anilino quinoline inhibitor

The structure was published by Angell, R.M., Bamborough, P., Cleasby, A., et al., Mooney, C.J., Somers, D.O., and Walker, A.L., in 2008 in a paper entitled "Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 345 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) MAP kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch protein serine/threonine kinase activitysearch transferase activitysearch protein kinase activitysearch NFAT protein bindingsearch kinase activitysearch nucleotide bindingsearch MAP kinase kinase activitysearch protein phosphorylationsearch mRNA metabolic processsearch stress-activated MAPK cascadesearch regulation of transcription from RNA polymerase II promotersearch osteoclast differentiationsearch positive regulation of myoblast differentiationsearch regulation of transcription, DNA-templatedsearch signal transductionsearch chondrocyte differentiationsearch positive regulation of reactive oxygen species metabolic processsearch cellular component movementsearch platelet activationsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch 3'-UTR-mediated mRNA stabilizationsearch positive regulation of erythrocyte differentiationsearch response to muramyl dipeptidesearch peptidyl-serine phosphorylationsearch cellular response to ionizing radiationsearch cellular response to lipopolysaccharidesearch transcription, DNA-templatedsearch Ras protein signal transductionsearch positive regulation of myoblast fusionsearch response to stresssearch angiogenesissearch activation of MAPK activitysearch signal transduction in response to DNA damagesearch toll-like receptor 5 signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch p38MAPK cascadesearch MyD88-dependent toll-like receptor signaling pathwaysearch negative regulation of canonical Wnt signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch toll-like receptor signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch response to lipopolysaccharidesearch positive regulation of muscle cell differentiationsearch lipopolysaccharide-mediated signaling pathwaysearch toll-like receptor 3 signaling pathwaysearch toll-like receptor 4 signaling pathwaysearch cell morphogenesissearch cell surface receptor signaling pathwaysearch vascular endothelial growth factor receptor signaling pathwaysearch gene expressionsearch cartilage condensationsearch phosphorylationsearch innate immune responsesearch positive regulation of protein import into nucleussearch apoptotic processsearch intracellular signal transductionsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch striated muscle cell differentiationsearch myoblast differentiation involved in skeletal muscle regenerationsearch toll-like receptor 9 signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch muscle cell differentiationsearch neurotrophin TRK receptor signaling pathwaysearch DNA damage checkpointsearch cellular response to vascular endothelial growth factor stimulussearch chemotaxissearch blood coagulationsearch glucose metabolic processsearch cellular response to DNA damage stimulussearch fatty acid oxidationsearch stress-induced premature senescencesearch positive regulation of myotube differentiationsearch skeletal muscle tissue developmentsearch RNA metabolic processsearch positive regulation of blood vessel endothelial cell migrationsearch cytoplasmsearch nucleussearch nucleoplasmsearch spindle polesearch extracellular vesicular exosomesearch cytosolsearch cellsearch mitochondrionsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch