2zas Summary


Crystal structure of human estrogen-related receptor gamma ligand binding domain complex with 4-alpha-cumylphenol, a bisphenol A derivative

The structure was published by Matsushima, A., Teramoto, T., Okada, H., et al., Tokunaga, T., Kakuta, Y., and Shimohigashi, Y., in 2008 in a paper entitled "ERRgamma tethers strongly bisphenol A and 4-alpha-cumylphenol in an induced-fit manner" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Estrogen-related receptor gamma. This molecule has the UniProt identifier P62508 (ERR3_HUMAN)search. The sample contained 244 residues which is < 90% of the natural sequence. Out of 244 residues 227 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Estrogen-related receptor gamma P62508 (222-458) (ERR3_HUMAN)search Homo sapienssearch < 90% 244 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P62508 (222 - 458) Estrogen-related receptor gamma Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P62508) DNA bindingsearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch steroid hormone mediated signaling pathwaysearch regulation of transcription, DNA-templatedsearch nucleussearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch