2z8c Summary


Phosphorylated insulin receptor tyrosine kinase in complex with (4-{[5-carbamoyl-4-(3-methylanilino)pyrimidin-2-yl]amino}phenyl)acetic acid

The structure was published by Katayama, N., Orita, M., Yamaguchi, T., et al., Matsumoto, Y., Fujita, S., and Niimi, T., in 2008 in a paper entitled "Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.25 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Insulin receptor and 6-mer peptide from Insulin receptor substrate 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Insulin receptor P06213 (1008-1310) (INSR_HUMAN)search Homo sapienssearch < 90% 303 99%
B 6-mer peptide from Insulin receptor substrate 1 P10747 (190-194) (CD28_HUMAN)search Homo sapienssearch < 90% 6 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P06213 (1008 - 1310) Insulin receptor Homo sapiens
P10747 (190 - 194) 6-mer peptide from Insulin receptor substrate 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P06213) ATP bindingsearch protein kinase activitysearch transmembrane receptor protein tyrosine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch protein phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch membranesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class II, conserved sitesearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch