2z8c › Citations

Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors.

Katayama N, Orita M, Yamaguchi T, Hisamichi H, Kuromitsu S, Kurihara H, Sakashita H, Matsumoto Y, Fujita S, Niimi T
Proteins 73 795-801 (2008)
Cited: 11 times
EuropePMC logo PMID: 18767165

Abstract

In this article, we report crystal structures for inhibitor-kinase complexes in which the inhibitor has different binding orientations and hydrogen-bonding patterns with extracellular-signal regulated kinase 2 and insulin receptor tyrosine kinase. Our crystallographic studies, and sequence and structural analyses of 532 coordinates of kinases held in the Protein Data Bank, suggest that the length of the "specificity linker" described here is a key structural element of the hydrogen-bonding patterns between protein kinases and their inhibitors.

Articles - 2z8c mentioned but not cited (8)

  1. Automated refinement of macromolecular structures at low resolution using prior information. Kovalevskiy O, Nicholls RA, Murshudov GN. Acta Crystallogr D Struct Biol 72 1149-1161 (2016)
  2. Protocatechuic Acid, a Phenolic from Sansevieria roxburghiana Leaves, Suppresses Diabetic Cardiomyopathy via Stimulating Glucose Metabolism, Ameliorating Oxidative Stress, and Inhibiting Inflammation. Bhattacharjee N, Dua TK, Khanra R, Joardar S, Nandy A, Saha A, De Feo V, Dewanjee S. Front Pharmacol 8 251 (2017)
  3. A Comprehensive Survey of the Roles of Highly Disordered Proteins in Type 2 Diabetes. Du Z, Uversky VN. Int J Mol Sci 18 E2010 (2017)
  4. S-Allylmercaptocysteine improves alcoholic liver disease partly through a direct modulation of insulin receptor signaling. Luo P, Zheng M, Zhang R, Zhang H, Liu Y, Li W, Sun X, Yu Q, Tipoe GL, Xiao J. Acta Pharm Sin B 11 668-679 (2021)
  5. Conformational transition paths harbor structures useful for aiding drug discovery and understanding enzymatic mechanisms in protein kinases. Wong CF. Protein Sci 25 192-203 (2016)
  6. A Drug-Target Network-Based Approach to Evaluate the Efficacy of Medicinal Plants for Type II Diabetes Mellitus. Gu J, Chen L, Yuan G, Xu X. Evid Based Complement Alternat Med 2013 203614 (2013)
  7. First Reports of Effects of Insulin, Human-like Insulin Receptors and Adapter Proteins in Acanthamoeba castellanii. Baig AM, Khaleeq A. Sci Rep 10 11759 (2020)
  8. Virtual screening of specific insulin-like growth factor 1 receptor (IGF1R) inhibitors from the National Cancer Institute (NCI) molecular database. Fan C, Huang YX, Bao YL, Sun LG, Wu Y, Yu CL, Zhang Y, Song ZB, Zheng LH, Sun Y, Wang GN, Li YX. Int J Mol Sci 13 17185-17209 (2012)


Reviews citing this publication (1)

  1. Development of extracellular signal-regulated kinase inhibitors. Burkhard K, Smith S, Deshmukh R, MacKerell AD, Shapiro P. Curr Top Med Chem 9 678-689 (2009)

Articles citing this publication (2)

  1. A computational workflow for the design of irreversible inhibitors of protein kinases. Del Rio A, Sgobba M, Parenti MD, Degliesposti G, Forestiero R, Percivalle C, Conte PF, Freccero M, Rastelli G. J Comput Aided Mol Des 24 183-194 (2010)
  2. A highly selective dual insulin receptor (IR)/insulin-like growth factor 1 receptor (IGF-1R) inhibitor derived from an extracellular signal-regulated kinase (ERK) inhibitor. Anastassiadis T, Duong-Ly KC, Deacon SW, Lafontant A, Ma H, Devarajan K, Dunbrack RL, Wu J, Peterson JR. J Biol Chem 288 28068-28077 (2013)


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