2z7s Summary

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Crystal Structure of the N-terminal Kinase Domain of Human RSK1 bound to Purvalnol A

The structure was published by Ikuta, M., Kornienko, M., Byrne, N., et al., Mizuarai, S., Kotani, H., and Munshi, S.K., in 2007 in a paper entitled "Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2007.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Ribosomal protein S6 kinase alpha-1. This molecule has the UniProt identifier Q15418 (KS6A1_HUMAN)search. The sample contained 321 residues which is < 90% of the natural sequence. Out of 321 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Ribosomal protein S6 kinase alpha-1 Q15418 (33-353) (KS6A1_HUMAN)search Homo sapienssearch < 90% 321 79%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q15418 (33 - 353) Ribosomal protein S6 kinase alpha-1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch, Protein kinase C terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (Q15418) ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein serine/threonine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch