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Crystal Structure of the N-terminal Kinase Domain of Human RSK1 bound to Purvalnol A

X-ray diffraction
2.1Å resolution
PDB entry 2z7s coloured by chain, front view.
PDB entry 2z7s coloured by chain, side view.
PDB entry 2z7s coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Ribosomal protein S6 kinase alpha-1
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Multimeric state: monomeric
Accessible surface area: 12659.22 Å2
Buried surface area: 753.43 Å2
Dissociation area: 376.71 Å2
Dissociation energy (ΔGdiss): -0.57 kcal/mol
Dissociation entropy (TΔSdiss): 4.74 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172282

Macromolecules

Ribosomal protein S6 kinase alpha-1
Chain: A
Length: 321 amino acids
Theoretical weight: 36.78 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q15418 (Residues: 33-353; Coverage: 44%)
Gene names: MAPKAPK1A, RPS6KA1, RSK1
Pfam: Protein kinase domain
InterPro:
CATH:
Ribosomal protein S6 kinase alpha-1 in PDB entry 2z7s, assembly 1, front view.
Ribosomal protein S6 kinase alpha-1 in PDB entry 2z7s, assembly 1, side view.
Ribosomal protein S6 kinase alpha-1 in PDB entry 2z7s, assembly 1, top view.
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