2z5y Summary


Crystal Structure of Human Monoamine Oxidase A (G110A) with Harmine

The structure was published by Son, S.Y., Ma, J., Kondou, Y., Yoshimura, M., Yamashita, E., and Tsukihara, T., in 2008 in a paper entitled "Structure of human monoamine oxidase A at 2.2-A resolution: The control of opening the entry for substrates/inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.17 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Amine oxidase [flavin-containing] A. This molecule has the UniProt identifier P21397 (AOFA_HUMAN)search. The sample contained 513 residues which is 97% of the natural sequence. Out of 513 residues 512 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Amine oxidase [flavin-containing] A P21397 (12-524) (AOFA_HUMAN)search Homo sapienssearch 97% 513 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P21397 (12 - 524) Amine oxidase [flavin-containing] A Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P21397) FAD/NAD(P)-binding domainsearch PF01593: Flavin containing amine oxidoreductasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P21397) oxidoreductase activitysearch primary amine oxidase activitysearch integral component of membranesearch mitochondrionsearch mitochondrial outer membranesearch membranesearch neurotransmitter biosynthetic processsearch small molecule metabolic processsearch oxidation-reduction processsearch cellular biogenic amine metabolic processsearch neurotransmitter secretionsearch dopamine catabolic processsearch catecholamine metabolic processsearch xenobiotic metabolic processsearch neurotransmitter catabolic processsearch synaptic transmissionsearch

Chain InterPro annotation
A Flavin amine oxidasesearch Amine oxidasesearch