2z5i Summary

pdbe.org/2z5i
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Crystal structure of the head-to-tail junction of tropomyosin

The structure was published by Murakami, K., Stewart, M., Nozawa, K., et al., Wakatsuki, S., Yasunaga, T., and Wakabayashi, T., in 2008 in a paper entitled "Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely General control protein GCN4 and Tropomyosin alpha-1 chain and Tropomyosin alpha-1 chain and General control protein GCN4.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A General control protein GCN4 and Tropomyosin alpha-1 chain P03069 (259-278) (GCN4_YEAST)search ,
P58772 (254-284) (TPM1_RABIT)search
Saccharomyces cerevisiae S288csearch ,
Oryctolagus cuniculussearch
< 90% ,
98%
52 96%
B General control protein GCN4 and Tropomyosin alpha-1 chain P03069 (259-278) (GCN4_YEAST)search ,
P58772 (254-284) (TPM1_RABIT)search
Saccharomyces cerevisiae S288csearch ,
Oryctolagus cuniculussearch
< 90% ,
98%
52 96%
C General control protein GCN4 and Tropomyosin alpha-1 chain P03069 (259-278) (GCN4_YEAST)search ,
P58772 (254-284) (TPM1_RABIT)search
Saccharomyces cerevisiae S288csearch ,
Oryctolagus cuniculussearch
< 90% ,
98%
52 96%
D General control protein GCN4 and Tropomyosin alpha-1 chain P03069 (259-278) (GCN4_YEAST)search ,
P58772 (254-284) (TPM1_RABIT)search
Saccharomyces cerevisiae S288csearch ,
Oryctolagus cuniculussearch
< 90% ,
98%
52 96%
E General control protein GCN4 and Tropomyosin alpha-1 chain P03069 (259-278) (GCN4_YEAST)search ,
P58772 (254-284) (TPM1_RABIT)search
Saccharomyces cerevisiae S288csearch ,
Oryctolagus cuniculussearch
< 90% ,
98%
52 96%
F General control protein GCN4 and Tropomyosin alpha-1 chain P03069 (259-278) (GCN4_YEAST)search ,
P58772 (254-284) (TPM1_RABIT)search
Saccharomyces cerevisiae S288csearch ,
Oryctolagus cuniculussearch
< 90% ,
98%
52 96%
G General control protein GCN4 and Tropomyosin alpha-1 chain P03069 (259-278) (GCN4_YEAST)search ,
P58772 (254-284) (TPM1_RABIT)search
Saccharomyces cerevisiae S288csearch ,
Oryctolagus cuniculussearch
< 90% ,
98%
52 96%
H General control protein GCN4 and Tropomyosin alpha-1 chain P03069 (259-278) (GCN4_YEAST)search ,
P58772 (254-284) (TPM1_RABIT)search
Saccharomyces cerevisiae S288csearch ,
Oryctolagus cuniculussearch
< 90% ,
98%
52 96%
I Tropomyosin alpha-1 chain and General control protein GCN4 P03069 (267-278) (GCN4_YEAST)search ,
P58772 (1-24) (TPM1_RABIT)search
Saccharomyces cerevisiae S288csearch ,
Oryctolagus cuniculussearch
< 90% ,
98%
40 90%
J Tropomyosin alpha-1 chain and General control protein GCN4 P03069 (267-278) (GCN4_YEAST)search ,
P58772 (1-24) (TPM1_RABIT)search
Saccharomyces cerevisiae S288csearch ,
Oryctolagus cuniculussearch
< 90% ,
98%
40 90%


Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F, G, H (P58772) Single alpha-helices involved in coiled-coils or other helix-helix interfacessearch PF00261: Tropomyosinsearch
I, J (P58772)
Chain InterPro annotation
A, B, C, D, E, F, G, H Tropomyosinsearch
I, J