2z5h Summary

pdbe.org/2z5h
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Crystal structure of the head-to-tail junction of tropomyosin complexed with a fragment of TnT

The structure was published by Murakami, K., Stewart, M., Nozawa, K., et al., Wakatsuki, S., Yasunaga, T., and Wakabayashi, T., in 2008 in a paper entitled "Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.89 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely General control protein GCN4 and Tropomyosin alpha-1 chain, Tropomyosin alpha-1 chain and General control protein GCN4, and Troponin T, fast skeletal muscle isoforms.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A General control protein GCN4 and Tropomyosin alpha-1 chain P03069 (259-278) (GCN4_YEAST)search ,
P58772 (254-284) (TPM1_RABIT)search
Saccharomyces cerevisiae S288csearch ,
Oryctolagus cuniculussearch
< 90% ,
98%
52 100%
B General control protein GCN4 and Tropomyosin alpha-1 chain P03069 (259-278) (GCN4_YEAST)search ,
P58772 (254-284) (TPM1_RABIT)search
Saccharomyces cerevisiae S288csearch ,
Oryctolagus cuniculussearch
< 90% ,
98%
52 100%
C General control protein GCN4 and Tropomyosin alpha-1 chain P03069 (259-278) (GCN4_YEAST)search ,
P58772 (254-284) (TPM1_RABIT)search
Saccharomyces cerevisiae S288csearch ,
Oryctolagus cuniculussearch
< 90% ,
98%
52 100%
D General control protein GCN4 and Tropomyosin alpha-1 chain P03069 (259-278) (GCN4_YEAST)search ,
P58772 (254-284) (TPM1_RABIT)search
Saccharomyces cerevisiae S288csearch ,
Oryctolagus cuniculussearch
< 90% ,
98%
52 100%
E General control protein GCN4 and Tropomyosin alpha-1 chain P03069 (259-278) (GCN4_YEAST)search ,
P58772 (254-284) (TPM1_RABIT)search
Saccharomyces cerevisiae S288csearch ,
Oryctolagus cuniculussearch
< 90% ,
98%
52 100%
F General control protein GCN4 and Tropomyosin alpha-1 chain P03069 (259-278) (GCN4_YEAST)search ,
P58772 (254-284) (TPM1_RABIT)search
Saccharomyces cerevisiae S288csearch ,
Oryctolagus cuniculussearch
< 90% ,
98%
52 100%
G General control protein GCN4 and Tropomyosin alpha-1 chain P03069 (259-278) (GCN4_YEAST)search ,
P58772 (254-284) (TPM1_RABIT)search
Saccharomyces cerevisiae S288csearch ,
Oryctolagus cuniculussearch
< 90% ,
98%
52 100%
H General control protein GCN4 and Tropomyosin alpha-1 chain P03069 (259-278) (GCN4_YEAST)search ,
P58772 (254-284) (TPM1_RABIT)search
Saccharomyces cerevisiae S288csearch ,
Oryctolagus cuniculussearch
< 90% ,
98%
52 100%
I Tropomyosin alpha-1 chain and General control protein GCN4 P03069 (267-278) (GCN4_YEAST)search ,
P58772 (1-24) (TPM1_RABIT)search
Saccharomyces cerevisiae S288csearch ,
Oryctolagus cuniculussearch
< 90% ,
98%
40 97%
T Troponin T, fast skeletal muscle isoforms P12620 (58-112) (TNNT3_CHICK)search Gallus gallussearch < 90% 55 61%


Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F, G, H (P58772) Tropomyosinsearch Single alpha-helices involved in coiled-coils or other helix-helix interfacessearch PF00261: Tropomyosinsearch
I (P58772)
T Troponinsearch

Chain ID Cellular component (GO) Biological process (GO)
T (P12620) troponin complexsearch regulation of muscle contractionsearch regulation of striated muscle contractionsearch

Chain InterPro annotation
A, B, C, D, E, F, G, H Tropomyosinsearch
I
T Troponinsearch Troponin Tsearch Troponin T, fast skeletal musclesearch