2z4j Summary


Crystal structure of AR LBD with SHP peptide NR Box 2

The structure was published by Jouravel, N., Sablin, E., Arnold, L.A., Guy, R.K., and Fletterick, R.J., in 2007 in a paper entitled "Interaction between the androgen receptor and a segment of its corepressor SHP" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Androgen receptor and Nuclear receptor 0B2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Androgen receptor P10275 (671-918) (ANDR_HUMAN)search Homo sapienssearch < 90% 248 100%
B Nuclear receptor 0B2 Q15466 (115-124) (NR0B2_HUMAN)search Homo sapienssearch < 90% 10 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P10275 (671 - 918) Androgen receptor Homo sapiens
Q15466 (115 - 124) Nuclear receptor 0B2

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
B Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P10275) steroid hormone receptor activitysearch DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch nucleussearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch