› 2z2w

X-ray diffraction
2.22Å resolution

Human Wee1 kinase complexed with inhibitor PF0335770

Released:
DOI: 10.2210/pdb2z2w/pdb
PDB entry 2z2w coloured by chain, front view.
PDB entry 2z2w coloured by chain, side view.
PDB entry 2z2w coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Squire CJ, Baker EN

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151698 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Wee1-like protein kinase Chain: A
Molecule details ›
Chain: A
Length: 285 amino acids
Theoretical weight: 32.18 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P30291 (Residues: 291-575; Coverage: 44%)
Gene name: WEE1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand CL 1 x CL
Ligand 770 1 x 770
Ligand GOL 1 x GOL
1 modified residue:
Ligand CSO 1 x CSO

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P41212
Unit cell:
a: 69.747Å b: 69.747Å c: 157.215Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.215 0.271
Expression system: Spodoptera frugiperda

Quick links