PDB entry 2ywp (supersedes 2fga)
Crystal Structure of CHK1 with a Urea Inhibitor
The structure was published by Li, G., Hasvold, L.A., Tao, Z.-F., et al., Sowin, T., Rosenberg, S.H., and Lin, N.-H., in 2006 in a paper entitled "Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2007.
The experimental data on which the structure is based was not deposited.
The PDB entry contains the structure of Serine/threonine-protein kinase Chk1. This molecule has the UniProt identifier O14757 (CHK1_HUMAN). The sample contained 269 residues which is < 90% of the natural sequence. Out of 269 residues 269 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: