Structure of L1196M Mutant Anaplastic Lymphoma Kinase
The structure was published by Huang, Q., Johnson, T.W., Bailey, S., et al., Zhu, J., Zou, H.Y., and Edwards, M.P., in 2014 in a paper entitled "Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2011.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of ALK TYROSINE KINASE RECEPTOR. This molecule has the UniProt identifier Q9UM73 (ALK_HUMAN). The sample contained 342 residues which is < 90% of the natural sequence. Out of 342 residues 291 were observed and are deposited in the PDB.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: