2yhv Summary


Structure of L1196M Mutant Anaplastic Lymphoma Kinase

The structure was published by Huang, Q., Johnson, T.W., Bailey, S., et al., Zhu, J., Zou, H.Y., and Edwards, M.P., in 2014 in a paper entitled "Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of ALK TYROSINE KINASE RECEPTOR. This molecule has the UniProt identifier Q9UM73 (ALK_HUMAN)search. The sample contained 342 residues which is < 90% of the natural sequence. Out of 342 residues 291 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ALK TYROSINE KINASE RECEPTOR Q9UM73 (1093-1411) (ALK_HUMAN)search Homo sapienssearch < 90% 342 85%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9UM73 (1093 - 1411) ALK TYROSINE KINASE RECEPTOR Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q9UM73) transmembrane receptor protein tyrosine kinase activitysearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch protein phosphorylationsearch phosphorylationsearch neuron developmentsearch activation of MAPK activitysearch signal transductionsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch membranesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class II, conserved sitesearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch ALK tyrosine kinase receptorsearch