2ygw Summary


Crystal structure of human MCD

The structure was published by Froese, D.S., Forouhar, F., Tran, T.H., et al., Oppermann, U., Yue, W.W., and Tong, L., in 2013 in a paper entitled "Crystal Structures of Malonyl-Coenzyme a Decarboxylase Provide Insights Into its Catalytic Mechanism and Disease-Causing Mutations." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of MALONYL-COA DECARBOXYLASE, MITOCHONDRIAL.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MALONYL-COA DECARBOXYLASE, MITOCHONDRIAL O95822 (40-490) (DCMC_HUMAN)search Homo sapienssearch 91% 460 90%
B MALONYL-COA DECARBOXYLASE, MITOCHONDRIAL O95822 (40-490) (DCMC_HUMAN)search Homo sapienssearch 91% 460 90%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB

Chain Sequence family (Pfam)
A, B (O95822) PF05292: Malonyl-CoA decarboxylase (MCD)search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (O95822) malonyl-CoA decarboxylase activitysearch carboxy-lyase activitysearch receptor bindingsearch lyase activitysearch fatty acid metabolic processsearch acetyl-CoA biosynthetic processsearch fatty acid biosynthetic processsearch malonyl-CoA catabolic processsearch positive regulation of fatty acid oxidationsearch regulation of fatty acid beta-oxidationsearch regulation of glucose metabolic processsearch response to ischemiasearch small molecule metabolic processsearch cellular lipid metabolic processsearch lipid metabolic processsearch regulation of fatty acid oxidationsearch fatty acid oxidationsearch peroxisomal matrixsearch mitochondrial matrixsearch cytoplasmsearch mitochondrionsearch peroxisomesearch cytosolsearch

Chain InterPro annotation
A, B Malonyl-CoA decarboxylasesearch