2ygw Summary


Crystal structure of human MCD

The structure was published by Froese, D.S., Forouhar, F., Tran, T.H., et al., Oppermann, U., Yue, W.W., and Tong, L., in 2013 in a paper entitled "Crystal Structures of Malonyl-Coenzyme a Decarboxylase Provide Insights Into its Catalytic Mechanism and Disease-Causing Mutations." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of MALONYL-COA DECARBOXYLASE, MITOCHONDRIAL.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MALONYL-COA DECARBOXYLASE, MITOCHONDRIAL O95822 (40-490) (DCMC_HUMAN)search Homo sapienssearch 91% 460 90%
B MALONYL-COA DECARBOXYLASE, MITOCHONDRIAL O95822 (40-490) (DCMC_HUMAN)search Homo sapienssearch 91% 460 90%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB

Chain Sequence family (Pfam)
A, B (O95822) PF05292: Malonyl-CoA decarboxylase (MCD)search

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (O95822) mitochondrionsearch mitochondrial matrixsearch peroxisomal matrixsearch cytoplasmsearch peroxisomesearch malonyl-CoA catabolic processsearch response to ischemiasearch regulation of glucose metabolic processsearch fatty acid biosynthetic processsearch acetyl-CoA biosynthetic processsearch fatty acid metabolic processsearch positive regulation of fatty acid oxidationsearch cellular lipid metabolic processsearch lipid metabolic processsearch small molecule metabolic processsearch malonyl-CoA decarboxylase activitysearch receptor bindingsearch carboxy-lyase activitysearch lyase activitysearch

Chain InterPro annotation
A, B Malonyl-CoA decarboxylasesearch