2ya9 Summary

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CRYSTAL STRUCTURE OF THE AUTOINHIBITED FORM OF MOUSE DAPK2

The structure was published by Patel, A.K., Yadav, R.P., Majava, V., Kursula, I., and Kursula, P., in 2011 in a paper entitled "Structure of the Dimeric Autoinhibited Conformation of Dapk2, a Pro-Apoptotic Protein Kinase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of DEATH-ASSOCIATED PROTEIN KINASE 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A DEATH-ASSOCIATED PROTEIN KINASE 2 Q8VDF3 (11-370) (DAPK2_MOUSE)search Mus musculussearch 97% 361 82%
B DEATH-ASSOCIATED PROTEIN KINASE 2 Q8VDF3 (11-370) (DAPK2_MOUSE)search Mus musculussearch 97% 361 82%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q8VDF3 (11 - 370) DEATH-ASSOCIATED PROTEIN KINASE 2 Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (Q8VDF3) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (Q8VDF3) ATP bindingsearch kinase activitysearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch calmodulin-dependent protein kinase activitysearch transferase activitysearch calmodulin bindingsearch protein kinase activitysearch nucleotide bindingsearch identical protein bindingsearch cytoplasmsearch autophagic vacuole lumensearch cytoplasmic vesiclesearch regulation of intrinsic apoptotic signaling pathwaysearch anoikissearch protein phosphorylationsearch regulation of apoptotic processsearch apoptotic processsearch intracellular signal transductionsearch phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Myosin light chain kinase-relatedsearch