2ya5 Summary

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CRYSTAL STRUCTURE OF STREPTOCOCCUS PNEUMONIAE NANA (TIGR4) IN COMPLEX WITH SIALIC ACID

The structure was published by Gut, H., Xu, G., Taylor, G.L., and Walsh, M.A., in 2011 in a paper entitled "Structural Basis for Streptococcus Pneumoniae Nana Inhibition by Influenza Antivirals Zanamivir and Oseltamivir Carboxylate." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of NEURAMINIDASE A.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A NEURAMINIDASE A P62575 (318-791) (NANA_STREE)search Streptococcus pneumoniaesearch < 90% 493 95%
B NEURAMINIDASE A P62575 (318-791) (NANA_STREE)search Streptococcus pneumoniaesearch < 90% 493 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P62575 (318 - 791) NEURAMINIDASE A Streptococcus pneumoniae TIGR4

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Neuraminidasesearch BNR repeat-like domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P62575) exo-alpha-sialidase activitysearch pathogenesissearch

Chain InterPro annotation
A, B Sialidasessearch Sialidase familysearch