2y5y Summary

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CRYSTAL STRUCTURE OF LACY IN COMPLEX WITH AN AFFINITY INACTIVATOR

The structure was published by Chaptal, V., Kwon, S., Sawaya, M.R., Guan, L., Kaback, H.R., and Abramson, J., in 2011 in a paper entitled "Crystal Structure of Lactose Permease in Complex with an Affinity Inactivator Yields Unique Insight Into Sugar Recognition." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.38 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of LACTOSE PERMEASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A LACTOSE PERMEASE P02920 (1-417) (LACY_ECOLI)search Escherichia coli K-12search 100% 423 93%
B LACTOSE PERMEASE P02920 (1-417) (LACY_ECOLI)search Escherichia coli K-12search 100% 423 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P02920 (1 - 417) LACTOSE PERMEASE Escherichia coli K-12

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P02920) MFS general substrate transporter like domainssearch PF01306: LacY proton/sugar symportersearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (P02920) membranesearch plasma membranesearch integral component of membranesearch integral component of plasma membranesearch transmembrane transportsearch lactose transportsearch carbohydrate transportsearch proton transportsearch transportsearch sugar:proton symporter activitysearch lactose:proton symporter activitysearch symporter activitysearch lactose bindingsearch

Chain InterPro annotation
A, B LacY/RafB permease familysearch LacY/RafB permease family, conserved sitesearch Major facilitator superfamily domainsearch