› 2y3j

X-ray diffraction
1.99Å resolution

Structure of segment AIIGLM from the amyloid-beta peptide (Ab, residues 30-35)

Released:
DOI: 10.2210/pdb2y3j/pdb
PDB entry 2y3j coloured by chain, front view.
PDB entry 2y3j coloured by chain, side view.
PDB entry 2y3j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis for amyloid-beta polymorphism.
Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D
Proc Natl Acad Sci U S A 108 16938-43 (2011)
PMID: 21949245

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138399 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P3(40) Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 6 amino acids
Theoretical weight: 617 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 701-706; Coverage: 1%)
Gene names: A4, AD1, APP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P1
Unit cell:
a: 9.56Å b: 15.64Å c: 45.23Å
α: 89.87° β: 90.02° γ: 89.91°
R-values:
R R work R free
0.225 0.222 0.267
Expression system: Not provided

Quick links

Citations

39 review citations

The amyloid state of proteins in human diseases.
Eisenberg et al. (2012)
38 more

15 mentions without citation

Functional Amyloids.
Otzen et al. (2019)
14 more