2xzj Summary

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THE ASPERGILLUS FUMIGATUS SIALIDASE IS A KDNASE: STRUCTURAL AND MECHANISTIC INSIGHTS

The structure was published by Telford, J.C., Yeung, J.H., Xu, G., et al., Bennet, A.J., Moore, M.M., and Taylor, G.L., in 2011 in a paper entitled "The Aspergillus Fumigatus Sialidase is a Kdnase: Structural and Mechanistic Insights." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.84 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of EXTRACELLULAR SIALIDASE/NEURAMINIDASE, PUTATIVE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A EXTRACELLULAR SIALIDASE/NEURAMINIDASE, PUTATIVE Q4WQS0 (21-406) (SIA_ASPFU)search Aspergillus fumigatus Af293search 100% 386 100%
B EXTRACELLULAR SIALIDASE/NEURAMINIDASE, PUTATIVE Q4WQS0 (21-406) (SIA_ASPFU)search Aspergillus fumigatus Af293search 100% 386 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q4WQS0 (21 - 406) EXTRACELLULAR SIALIDASE/NEURAMINIDASE, PUTATIVE Aspergillus fumigatus Af293

Chain Sequence family (Pfam)
A, B (Q4WQS0) PF13088: BNR repeat-like domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (Q4WQS0) exo-alpha-sialidase activitysearch hydrolase activitysearch exo-alpha-(2->6)-sialidase activitysearch hydrolase activity, acting on glycosyl bondssearch exo-alpha-(2->3)-sialidase activitysearch exo-alpha-(2->8)-sialidase activitysearch metabolic processsearch biological_processsearch carbohydrate metabolic processsearch cellular_componentsearch

Chain InterPro annotation
A, B Sialidasessearch Sialidase familysearch