2xyn Summary


PDB entry 2xyn (supersedes 3nsv)


The structure was published by Salah, E., Ugochukwu, E., Barr, A.J., Von Delft, F., Knapp, S., and Elkins, J.M., in 2011 in a paper entitled "Crystal Structures of Abl-Related Gene (Abl2) in Complex with Imatinib, Tozasertib (Vx-680), and a Type I Inhibitor of the Triazole Carbothioamide Class." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.81 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of TYROSINE-PROTEIN KINASE ABL2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TYROSINE-PROTEIN KINASE ABL2 P42684 (279-546) (ABL2_HUMAN)search Homo sapienssearch < 90% 292 90%
B TYROSINE-PROTEIN KINASE ABL2 P42684 (279-546) (ABL2_HUMAN)search Homo sapienssearch < 90% 292 90%
C TYROSINE-PROTEIN KINASE ABL2 P42684 (279-546) (ABL2_HUMAN)search Homo sapienssearch < 90% 292 90%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P42684 (279 - 546) TYROSINE-PROTEIN KINASE ABL2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO)
A, B, C (P42684) protein phosphorylationsearch protein kinase activitysearch ATP bindingsearch protein tyrosine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A, B, C Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch