› 2xxx

X-ray diffraction
2.1Å resolution

Crystal structure of the GluK2 (GluR6) D776K LBD dimer in complex with glutamate (P21 21 21)

Released:
DOI: 10.2210/pdb2xxx/pdb
PDB entry 2xxx coloured by chain, front view.
PDB entry 2xxx coloured by chain, side view.
PDB entry 2xxx coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Conformational flexibility of the ligand-binding domain dimer in kainate receptor gating and desensitization.
Nayeem N, Mayans O, Green T
J Neurosci 31 2916-24 (2011)
PMID: 21414913

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154585 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 261 amino acids
Theoretical weight: 29.64 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P42260 (Residues: 429-544, 667-806; Coverage: 29%)
Gene names: Glur6, Grik2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:
Ligand GLU 4 x GLU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 85.56Å b: 101.341Å c: 125.697Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.179 0.231
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Hansen et al. (2021)
4 more

14 mentions without citation

Advancements in the Additive Manufacturing of Magnesium and Aluminum Alloys through Laser-Based Approach.
Sharma et al. (2022)
13 more