2xs6 Summary

pdbe.org/2xs6
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CRYSTAL STRUCTURE OF THE RHOGAP DOMAIN OF HUMAN PIK3R2

A publication describing this structure is not available. The depositing authors are Tresaugues, L.search; Welin, M.search; Arrowsmith, C.H.search; Berglund, H.search; Bountra, C.search; Collins, R.search; Edwards, A.M.search; Flodin, S.search; Flores, A.search; Graslund, S.search; Hammarstrom, M.search; Johansson, I.search; Karlberg, T.search; Kol, S.search; Kotenyova, T.search; Kouznetsova, E.search; Moche, M.search; Nyman, T.search; Persson, C.search; Schuler, H.search; Schutz, P.search; Siponen, M.I.search; Thorsell, A.G.search; Van Der Berg, S.search; Wahlberg, E.search; Weigelt, J.search; Nordlund, P.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.09 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA. This molecule has the UniProt identifier O00459 (P85B_HUMAN)search. The sample contained 214 residues which is < 90% of the natural sequence. Out of 214 residues 166 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA O00459 (108-298) (P85B_HUMAN)search Homo sapienssearch < 90% 214 77%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O00459 (108 - 298) PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A GTPase -GAP domainsearch RhoGAP domainsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (O00459) phosphatidylinositol 3-kinase complexsearch intracellularsearch signal transductionsearch phosphatidylinositol 3-kinase regulator activitysearch

Chain InterPro annotation
A Rho GTPase-activating protein domainsearch PI3 kinase, P85 regulatory subunitsearch Rho GTPase activation proteinsearch