2xr9 Summary



There is a Quite Interesting Protein Structure article for this entry.

The structure was published by Hausmann, J., Kamtekar, S., Christodoulou, E., et al., Morris, A.J., Moolenaar, W.H., and Perrakis, A., in 2011 in a paper entitled "Structural Basis of Substrate Discrimination and Integrin Binding by Autotaxin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.05 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 2. This molecule has the UniProt identifier Q64610 (ENPP2_RAT)search. The sample contained 827 residues which is 96% of the natural sequence. Out of 827 residues 782 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 2 Q64610 (36-887) (ENPP2_RAT)search Rattus norvegicussearch 96% 827 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB

Chain Sequence family (Pfam)
A (Q64610) PF01033: Somatomedin B domainsearch, PF01223: DNA/RNA non-specific endonucleasesearch, PF01663: Type I phosphodiesterase / nucleotide pyrophosphatasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q64610) metabolic processsearch chemotaxissearch immune responsesearch positive regulation of substrate adhesion-dependent cell spreadingsearch nucleic acid phosphodiester bond hydrolysissearch response to polycyclic arenesearch receptor-mediated endocytosissearch negative regulation of cell-matrix adhesionsearch positive regulation of oligodendrocyte differentiationsearch cellular response to estradiol stimulussearch phosphatidylcholine catabolic processsearch estrous cyclesearch lipid catabolic processsearch positive regulation of cell proliferationsearch cell chemotaxissearch cellular response to cadmium ionsearch lipid metabolic processsearch positive regulation of focal adhesion assemblysearch regulation of angiogenesissearch regulation of cell migrationsearch catalytic activitysearch metal ion bindingsearch scavenger receptor activitysearch lysophospholipase activitysearch polysaccharide bindingsearch phosphodiesterase I activitysearch nucleic acid bindingsearch alkylglycerophosphoethanolamine phosphodiesterase activitysearch hydrolase activitysearch calcium ion bindingsearch nucleotide diphosphatase activitysearch zinc ion bindingsearch Golgi apparatussearch cytoplasmsearch extracellular spacesearch extracellular regionsearch

Chain InterPro annotation
A Somatomedin B domainsearch DNA/RNA non-specific endonucleasesearch Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferasesearch Alkaline phosphatase-like, alpha/beta/alphasearch Alkaline-phosphatase-like, core domainsearch Somatomedin B, chordatasearch Extracellular Endonuclease, subunit Asearch Ectonucleotide pyrophosphatase/phosphodiesterase familysearch Ectonucleotide pyrophosphatase/phosphodiesterase family member 2search