2xr9 Summary

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CRYSTAL STRUCTURE OF AUTOTAXIN (ENPP2)

There is a Quite Interesting Protein Structure article for this entry.

The structure was published by Hausmann, J., Kamtekar, S., Christodoulou, E., et al., Morris, A.J., Moolenaar, W.H., and Perrakis, A., in 2011 in a paper entitled "Structural Basis of Substrate Discrimination and Integrin Binding by Autotaxin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.05 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 2. This molecule has the UniProt identifier Q64610 (ENPP2_RAT)search. The sample contained 827 residues which is 96% of the natural sequence. Out of 827 residues 782 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 2 Q64610 (36-887) (ENPP2_RAT)search Rattus norvegicussearch 96% 827 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q64610 (36 - 887) ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 2 Rattus norvegicus

Chain Sequence family (Pfam)
A (Q64610) PF01033: Somatomedin B domainsearch, PF01223: DNA/RNA non-specific endonucleasesearch, PF01663: Type I phosphodiesterase / nucleotide pyrophosphatasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (Q64610) nucleic acid bindingsearch catalytic activitysearch lysophospholipase activitysearch scavenger receptor activitysearch calcium ion bindingsearch zinc ion bindingsearch hydrolase activitysearch polysaccharide bindingsearch metal ion bindingsearch alkylglycerophosphoethanolamine phosphodiesterase activitysearch extracellular regionsearch extracellular spacesearch lipid metabolic processsearch receptor-mediated endocytosissearch chemotaxissearch immune responsesearch metabolic processsearch lipid catabolic processsearch phosphatidylcholine catabolic processsearch

Chain InterPro annotation
A Somatomedin B domainsearch DNA/RNA non-specific endonucleasesearch Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferasesearch Alkaline phosphatase-like, alpha/beta/alphasearch Alkaline-phosphatase-like, core domainsearch Somatomedin B, chordatasearch Extracellular Endonuclease, subunit Asearch Ectonucleotide pyrophosphatase/phosphodiesterase familysearch