DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION
The structure was published by Potter, A., Oldfield, V., Nunns, C., et al., Richardson, C.M., Murray, J.B., and Moore, J.D., in 2010 in a paper entitled "Discovery of Cell-Active Phenyl-Imidazole Pin1 Inhibitors by Structure-Guided Fragment Evolution." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2010.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 1. This molecule has the UniProt identifier Q13526 (PIN1_HUMAN). The sample contained 167 residues which is 100% of the natural sequence. Out of 167 residues 145 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: