2xp2 Summary

pdbe.org/2xp2
spacer

STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH CRIZOTINIB (PF-02341066)

The structure was published by Cui, J.J., Tran-Dube, M., Shen, H., et al., Bender, S., Kania, R.S., and Edwards, M.P., in 2011 in a paper entitled "Structure Based Drug Design of Crizotinib (Pf-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal-Epithelial Transition Factor (C-met) Kinase and Anaplastic Lymphoma Kinase (Alk)." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of TYROSINE-PROTEIN KINASE RECEPTOR. This molecule has the UniProt identifier Q9UM73 (ALK_HUMAN)search. The sample contained 327 residues which is < 90% of the natural sequence. Out of 327 residues 285 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TYROSINE-PROTEIN KINASE RECEPTOR Q9UM73 (1093-1411) (ALK_HUMAN)search Homo sapienssearch < 90% 327 88%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9UM73 (1093 - 1411) TYROSINE-PROTEIN KINASE RECEPTOR Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q9UM73) transmembrane receptor protein tyrosine kinase signaling pathwaysearch protein phosphorylationsearch activation of MAPK activitysearch neuron developmentsearch signal transductionsearch phosphorylationsearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein tyrosine kinase activitysearch transmembrane receptor protein tyrosine kinase activitysearch protein kinase activitysearch membranesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class II, conserved sitesearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch ALK tyrosine kinase receptorsearch