2xp2 Summary

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STRUCTURE OF THE HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH CRIZOTINIB (PF-02341066)

The structure was published by Cui, J.J., Tran-Dube, M., Shen, H., et al., Bender, S., Kania, R.S., and Edwards, M.P., in 2011 in a paper entitled "Structure Based Drug Design of Crizotinib (Pf-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal-Epithelial Transition Factor (C-met) Kinase and Anaplastic Lymphoma Kinase (Alk)." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of TYROSINE-PROTEIN KINASE RECEPTOR. This molecule has the UniProt identifier Q9UM73 (ALK_HUMAN)search. The sample contained 327 residues which is < 90% of the natural sequence. Out of 327 residues 285 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TYROSINE-PROTEIN KINASE RECEPTOR Q9UM73 (1093-1411) (ALK_HUMAN)search Homo sapienssearch < 90% 327 88%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9UM73 (1093 - 1411) TYROSINE-PROTEIN KINASE RECEPTOR Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q9UM73) transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein kinase activitysearch protein tyrosine kinase activitysearch transmembrane receptor protein tyrosine kinase activitysearch signal transductionsearch phosphorylationsearch protein phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch neuron developmentsearch activation of MAPK activitysearch membranesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class II, conserved sitesearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch ALK tyrosine kinase receptorsearch