2xnx Summary

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BC1 FRAGMENT OF STREPTOCOCCAL M1 PROTEIN IN COMPLEX WITH HUMAN FIBRINOGEN

The structure was published by Macheboeuf, P., Buffalo, C., Fu, C.Y., et al., Nizet, V., Nizet, V., and Ghosh, P., in 2011 in a paper entitled "Streptococcal M1 Protein Constructs a Pathological Host Fibrinogen Network" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.3 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This entry contains 14 copies of 4 unique biopolymers (complete list).

The most likely quaternary structure is a 14meric assembly.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A FIBRINOGEN ALPHA CHAIN P02671 (130-216) (FIBA_HUMAN)search Homo sapienssearch < 90% 87 87%
D FIBRINOGEN ALPHA CHAIN P02671 (130-216) (FIBA_HUMAN)search Homo sapienssearch < 90% 87 87%
G FIBRINOGEN ALPHA CHAIN P02671 (130-216) (FIBA_HUMAN)search Homo sapienssearch < 90% 87 87%
J FIBRINOGEN ALPHA CHAIN P02671 (130-216) (FIBA_HUMAN)search Homo sapienssearch < 90% 87 87%
B FIBRINOGEN BETA CHAIN P02675 (164-491) (FIBB_HUMAN)search Homo sapienssearch 99% 328 95%
E FIBRINOGEN BETA CHAIN P02675 (164-491) (FIBB_HUMAN)search Homo sapienssearch 99% 328 95%
H FIBRINOGEN BETA CHAIN P02675 (164-491) (FIBB_HUMAN)search Homo sapienssearch 99% 328 95%
K FIBRINOGEN BETA CHAIN P02675 (164-491) (FIBB_HUMAN)search Homo sapienssearch 99% 328 95%
C FIBRINOGEN GAMMA CHAIN P02679 (114-432) (FIBG_HUMAN)search Homo sapienssearch 95% 319 95%
F FIBRINOGEN GAMMA CHAIN P02679 (114-432) (FIBG_HUMAN)search Homo sapienssearch 95% 319 95%
I FIBRINOGEN GAMMA CHAIN P02679 (114-432) (FIBG_HUMAN)search Homo sapienssearch 95% 319 95%
L FIBRINOGEN GAMMA CHAIN P02679 (114-432) (FIBG_HUMAN)search Homo sapienssearch 95% 319 95%
M M PROTEIN Q48WD8 (128-263) (Q48WD8_STRP1)search Streptococcus pyogenes serotype M1search < 90% 146 73%
N M PROTEIN Q48WD8 (128-263) (Q48WD8_STRP1)search Streptococcus pyogenes serotype M1search < 90% 146 73%


This entry contains 4 unique UniProt proteins:

UniProt accession Name Organism PDB
P02671 (130 - 216) FIBRINOGEN ALPHA CHAIN Homo sapiens
P02675 (164 - 491) FIBRINOGEN BETA CHAIN Homo sapiens
P02679 (114 - 432) FIBRINOGEN GAMMA CHAIN Homo sapiens
Q48WD8 (128 - 263) M PROTEIN Streptococcus pyogenes

Chain Structural classification (CATH) Sequence family (Pfam)
A, D, G, J Single alpha-helices involved in coiled-coils or other helix-helix interfacessearch Fibrinogen alpha/beta chain familysearch
B, E, H, K (P02675) Gamma Fibrinogen, chain A, domain 1search, Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2search PF00147: Fibrinogen beta and gamma chains, C-terminal globular domainsearch, PF08702: Fibrinogen alpha/beta chain familysearch
C, F, I, L (P02679) Gamma Fibrinogen, chain A, domain 1search, Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2search PF00147: Fibrinogen beta and gamma chains, C-terminal globular domainsearch, PF08702: Fibrinogen alpha/beta chain familysearch
M, N

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, D, G, J (P02671) platelet activationsearch signal transductionsearch protein polymerizationsearch fibrinogen complexsearch protein binding, bridgingsearch receptor bindingsearch
B, E, H, K (P02675) signal transductionsearch platelet activationsearch protein polymerizationsearch fibrinogen complexsearch receptor bindingsearch protein binding, bridgingsearch
C, F, I, L (P02679) platelet activationsearch signal transductionsearch protein polymerizationsearch fibrinogen complexsearch protein binding, bridgingsearch receptor bindingsearch

Chain InterPro annotation
A, D, G, J Fibrinogen, alpha/beta/gamma chain, coiled coil domainsearch
B, E, H, K Fibrinogen, alpha/beta/gamma chain, C-terminal globular domainsearch Fibrinogen, alpha/beta/gamma chain, coiled coil domainsearch Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2search Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1search Fibrinogen, conserved sitesearch
C, F, I, L Fibrinogen, alpha/beta/gamma chain, C-terminal globular domainsearch Fibrinogen, alpha/beta/gamma chain, coiled coil domainsearch Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2search Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1search Fibrinogen, conserved sitesearch
M, N