2xnn Summary

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STRUCTURE OF NEK2 BOUND TO CCT242430

The structure was published by Solanki, S., Innocenti, P., Mas-Droux, C., et al., Aherne, G.W., Bayliss, R., and Hoelder, S., in 2011 in a paper entitled "Benzimidazole Inhibitors Induce a Dfg-Out Conformation of Never in Mitosis Gene A-Related Kinase 2 (Nek2) without Binding to the Back Pocket and Reveal a Nonlinear Structure-Activity Relationship." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of SERINE/THREONINE-PROTEIN KINASE NEK2. This molecule has the UniProt identifier P51955 (NEK2_HUMAN)search. The sample contained 279 residues which is < 90% of the natural sequence. Out of 279 residues 241 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SERINE/THREONINE-PROTEIN KINASE NEK2 P51955 (1-271) (NEK2_HUMAN)search Homo sapienssearch < 90% 279 89%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P51955 (1 - 271) SERINE/THREONINE-PROTEIN KINASE NEK2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch
Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch