STRUCTURE OF AURORA-A BOUND TO A SELECTIVE IMIDAZOPYRAZINE INHIBITOR
The structure was published by Bouloc, N., Large, J.M., Kosmopoulou, M., et al., Linardopoulos, S., Bayliss, R., and Bavetsias, V., in 2010 in a paper entitled "Structure-Based Design of Imidazo[1,2-A]Pyrazine Derivatives as Selective Inhibitors of Aurora-A Kinase in Cells." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.605 Å and deposited in 2010.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of SERINE/THREONINE-PROTEIN KINASE 6. This molecule has the UniProt identifier O14965 (AURKA_HUMAN). The sample contained 283 residues which is < 90% of the natural sequence. Out of 283 residues 238 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: