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Co-crystal structure of a small molecule inhibitor bound to the kinase domain of Chk2

X-ray diffraction
3.4Å resolution
PDB entry 2xm8 coloured by chain, front view.
PDB entry 2xm8 coloured by chain, side view.
PDB entry 2xm8 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine/threonine-protein kinase Chk2
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Multimeric state: homo dimer
Accessible surface area: 26365.72 Å2
Buried surface area: 1765.35 Å2
Dissociation area: 882.67 Å2
Dissociation energy (ΔGdiss): 0.76 kcal/mol
Dissociation entropy (TΔSdiss): 13.09 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-132134

Macromolecules

Serine/threonine-protein kinase Chk2
Chain: A
Length: 329 amino acids
Theoretical weight: 37.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O96017 (Residues: 210-531; Coverage: 59%)
Gene names: CDS1, CHEK2, CHK2, RAD53
Pfam: Protein kinase domain
InterPro:
CATH:
Serine/threonine-protein kinase Chk2 in PDB entry 2xm8, assembly 1, front view.
Serine/threonine-protein kinase Chk2 in PDB entry 2xm8, assembly 1, side view.
Serine/threonine-protein kinase Chk2 in PDB entry 2xm8, assembly 1, top view.
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