STRUCTURE OF NEK2 BOUND TO AMINOPYRAZINE COMPOUND 2
The structure was published by Whelligan, D.K., Solanki, S., Taylor, D., et al., Aherne, G.W., Bayliss, R., and Hoelder, S., in 2010 in a paper entitled "Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: Sar and Structural Characterization." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.35 Å and deposited in 2010.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of SERINE/THREONINE-PROTEIN KINASE NEK2. This molecule has the UniProt identifier P51955 (NEK2_HUMAN). The sample contained 279 residues which is < 90% of the natural sequence. Out of 279 residues 243 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: