STRUCTURE OF NEK2 BOUND TO AMINOPYRAZINE COMPOUND 14
The structure was published by Whelligan, D.K., Solanki, S., Taylor, D., et al., Aherne, G.W., Bayliss, R., and Hoelder, S., in 2010 in a paper entitled "Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: Sar and Structural Characterization." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2010.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of SERINE/THREONINE-PROTEIN KINASE NEK2. This molecule has the UniProt identifier P51955 (NEK2_HUMAN). The sample contained 279 residues which is < 90% of the natural sequence. Out of 279 residues 236 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: