STRUCTURAL ANALYSIS OF CHECKPOINT KINASE 2 (CHK2) IN COMPLEX WITH INHIBITOR PV1533
The structure was published by Lountos, G.T., Jobson, A.G., Tropea, J.E., et al., Pommier, Y., Shoemaker, R.H., and Waugh, D.S., in 2011 in a paper entitled "Structural Characterization of Inhibitor Complexes with Checkpoint Kinase 2 (Chk2), a Drug Target for Cancer Therapy." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.35 Å and deposited in 2010.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of CHECKPOINT KINASE 2. This molecule has the UniProt identifier O96017 (CHK2_HUMAN). The sample contained 322 residues which is < 90% of the natural sequence. Out of 322 residues 283 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule most likely forms homodimers.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: