2xk6 Summary

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STRUCTURE OF NEK2 BOUND TO AMINOPYRAZINE COMPOUND 36

The structure was published by Whelligan, D.K., Solanki, S., Taylor, D., et al., Aherne, G.W., Bayliss, R., and Hoelder, S., in 2010 in a paper entitled "Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: Sar and Structural Characterization." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of SERINE/THREONINE-PROTEIN KINASE NEK2. This molecule has the UniProt identifier P51955 (NEK2_HUMAN)search. The sample contained 279 residues which is < 90% of the natural sequence. Out of 279 residues 235 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SERINE/THREONINE-PROTEIN KINASE NEK2 P51955 (1-271) (NEK2_HUMAN)search Homo sapienssearch < 90% 279 87%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P51955 (1 - 271) SERINE/THREONINE-PROTEIN KINASE NEK2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P51955) ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein serine/threonine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch