› 2xgw

X-ray diffraction
2.1Å resolution

ZINC-BOUND CRYSTAL STRUCTURE OF STREPTOCOCCUS PYOGENES DPR

Released:
DOI: 10.2210/pdb2xgw/pdb
PDB entry 2xgw coloured by chain, front view.
PDB entry 2xgw coloured by chain, side view.
PDB entry 2xgw coloured by chain, top view.
Source organism: Streptococcus pyogenes
Primary publication:
Structural characterization and biological implications of di-zinc binding in the ferroxidase center of Streptococcus pyogenes Dpr.
Haikarainen T, Tsou CC, Wu JJ, Papageorgiou AC
Biochem Biophys Res Commun 398 361-5 (2010)
PMID: 20599728

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189420 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ferritin/DPS protein domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 199 amino acids
Theoretical weight: 22.06 KDa
Source organism: Streptococcus pyogenes
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q99YU7 (Residues: 1-175; Coverage: 100%)
Gene names: SPy_1531, dpr
Sequence domains: Ferritin-like domain
Structure domains: Ferritin

Ligands and Environments

4 bound ligands:
Ligand ZN 3 x ZN
Ligand CL 1 x CL
Ligand SIN 1 x SIN
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X12
Spacegroup: F4132
Unit cell:
a: 187.12Å b: 187.12Å c: 187.12Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.145 0.144 0.172
Expression system: Escherichia coli BL21

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Citations

5 review citations

Streptococcus pneumoniae and reactive oxygen species: an unusual approach to living with radicals.
Yesilkaya et al. (2013)
4 more